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KMID : 0367419630040020023
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Journal of Korean Pediatric Society
1963 Volume.4 No. 2 p.23 ~ p.42
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Studies on Normal Values for Red Blood Cells of Korean Infants and Children
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洪彰義/Hong, Chang Yee
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Abstract
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Summary - ,
1. This paper presents hematologic data on 1205 samples of blood from normal healthy Korean infants and children ranging in age from birth to 16 years.
The number of red blood cells, quantity of hemoglobin, volume of packed cells. the mean corpuscular diameter, and the number of reticulocytes have been determined. The indices of mean mean corpuscular
Pan corpuscular volume (MCV), 1~, hemoglobin (iviClf), and mean corpuscular hemoglobin concentration (MCHC) were calculated as usual, according to Wintrobe.
The children are divided into twenty-four groups according to age, and the arithmetical means with the respcctive standard deviations and standard errors are reported for each group. The sequence of changes in characteristics of the erythrocytes of infants and children at different ages was emphasized and the hematologic data were compared to those reported in various countries.
3. The average red cell count rose from 4.78 million in the cord blood to 5.10 million at one day and remained at the same level for the first one week and then decreased to the lowest level 4. 14 million between the ages of 1 and 3 months. Thereafter the red cell count rose gradually to 4.80 million at 14 years although there was a transient fall between the ages of II and 17 months.
4. The average values for hemoglobin increased form 17.25gm/lOOmlin the cord blood to 18.83 gm/ 100m1 at one day and then decreased to the lowest level, 11.63gm/lOOml at one year of age and thereafter increased slowly to 13. 96gm/l 00ml at 14years.
5. Hematocrit values increased from an average in the cord blood of 51. 03% to an average of 54.62% at one day and slowly decreased to the lowest level, 35.25% at l5months and thereafter it rose gradually to an average of 40.52% at 14years of age.
.6. There was a significant difference in mean values of red cell counts, hemoglobin and hematocrit between the capillary and venous blood sample in the newborn period. The capillary samples showed a significantly higher value than those from the vein. The difference was O.8millo n in red cell counts, 2.3Gm/lOOml in hemoglobin and 7.4% in hematocrit at one day and these differences have become less prominent gradually.
7. The mean corpuscular volume showed the highest value, 106. 8ym³ at one day and diminisned rapidly, reaching the lowest value, 74.9m³ at one year and thereafter increased slowly to 84.8m³ at 14years.
8. The highest value, 35. 7,γγ, , for the mean corpuscular hemoglobin is found in the cord blood and the M CH diminished showing a similar curve as in MCV, reachirg the lowest mean, 24.4 γγ. at 1 year. Thereafter the MCH increased slowly co an average of 28.9 Tr at 14years.
9. In contrast to the othei values, the mean corpuscular hemoglobin concentration remained at a remarkably uniform level, ranging from 32.9Gm/100ml_ to 34.7Gm/°lOOmi all through the pediatric age although it showed a slight increase during the early newborn period and then decreased again to the low level, 32.9Gm; 100mi at 1 year of age.
10. The mean corpuscular diameter was 8.54g at birth and decreased gradually to the lowest level of 7.33; at i year. Thereafter it increased gradually to 7.51- at 14years.
11. The n can values of reticulocyte counts showed a rapid change during the first seek of life, falling from. 3.24% at one day to 1.2% beyond one week of life. After the neonatal per od, the reticulocyte count showed no significant change and remained at approximately 1% all through the pediatric age.
12. During the neonatal period ail values for the erythrocvte showed a great variability both in individuals and between members of a group, as indicated by figures for standard deviations.
13. Based on the author´s data, threshold values for the diagnosis of anemia in Korean infants and children were proposed for practical purposes.
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KEYWORD
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